Reason is the main basis of Mu'tazili interpretation, and based on this, verses whose appearances are in conflict with the ruling of reason are analyzed. Mu'tazila considers reason as the first basis for understanding Sharia and Sharia as subordinate to it.Mu'tazila considers reason as the first basis for understanding Sharia and Sharia as subordinate to it. Neo-Mu'tazila ideas are rooted in the opinions of the first Mu'tazila thinkers in the early Islamic centuries, and they believe that due to the fluidity and history of the text of the Qur'an, its ideas can be modernized and, in fact, secularized and secularized.As a result, secularism can be inferred to mean the separation of religion from the government and not from politics in the ideas of the neo-Mutzlians.As a result, secularism can be inferred to mean the separation of religion from the government and not from politics in the ideas of the neo-Mutzlians. The present research examines the interpretive foundations of Mu'tazila and New 'Itzal, their differences and similarities, and their performance in the field of interpretation with the method of analyzing and reviewing existing works.The traditional and new Mu'tazila have turned to interpretations regarding the freedom of man in his actions, God's dispensation from incarnation and evil, rejection of superstitions and myths, and denial of intercession, and at the same time, they have been caught in a kind of extremism in intellectual interpretations.