Some key issues in the Quran-based human sciences have a significant effect on its richness, perfection and excellence. In fact, one of the foundations of the richness and perfection of human sciences based on the Qur'an is the depth of the divine book. The Holy Qur'an does not use the word "inner" or "stomach" around itself, but verse 7 of Surah Mubaraka Al-Imran, which mentions the interpretation of the divine book and by attaching the narrations explaining the interpretation to the inner, indicates the existence of the inner for the Holy Qur'an. Baten" is mentioned in the word as "inside and inside the object" and "hidden and covered" and according to authentic traditions, "Baten" is a meaning that the noble verses do not clearly imply according to the rules of Arabic literature, the rational principles of conversation and the customary concepts of words. In this article, an attempt has been made to research the role of the essence of the Holy Qur'an in the richness and perfection of human sciences based on the Qur'an through a descriptive-analytical method. In this article, an attempt has been made to research the role of the essence of the Holy Qur'an in the richness and perfection of human sciences based on the Qur'an through a descriptive-analytical method. One of the achievements of the research is that the introspection of the divine book provides the efforts of researchers to collect more noble verses and make maximum use of it for the production of human sciences