This research seeks to examine and analyze interpretive-hermeneutical theories related to the phrase “Huda lill-Muttaqiin” in the Holy Quran, focusing on Shiite perspectives and extracting different semantic dimensions of guidance and its relationship with concepts such as Ahl al-Bayt (AS), fitrat, Sharia, and absolute guardianship. The research method was conducted with a qualitative and analytical-interpretive approach. The data were collected through a review of authentic Shiite interpretations and works related to Shiite wisdom and mysticism, and were examined and interpreted using the content analysis method. The findings of this study show that in the interpretation of “Huda for the Pious,” guidance does not simply mean mental awareness, but rather an existential connection with the Ahl al-Bayt (AS), a success in preserving nature and avoiding doubts about faith, a spiritual connection with divine choice, a process from nature to law, the unity of path and destination, and finally a journey from the heart to absolute guardianship. Also, the guidance of the Holy Quran has been examined as an effective existence from mental implication to existential realization. The interpretative theories in the interpretation of “Huda for the Pious” reveal deep and broad dimensions of divine guidance and show that guidance, beyond awareness and knowledge, is an evolutionary and spiritual process that leads the believer towards perfection and divine closeness.