In the teachings of the Ahl al-Bayt (peace be upon them), interpretive narratives hold a special status as an important tool for understanding the divine intent. However, the role of interpretive rules in comprehending key Qur'anic concepts such as "Ḍalāl" has received less attention. This issue has posed a challenge to accessing a portion of Qur'anic knowledge. The present research, using a descriptive-analytical method, examines the semantic levels of the word "Ḍalāl" in the verses cited by Kulaynī in the book Al-Kāfī. The findings of this research clearly show that the concept of "Ḍalāl" in the Noble Qur'an has a coherent and multi-layered semantic structure that can only be grasped through a comprehensive approach to different semantic levels (apparent, esoteric, and exemplificative). The conducted analyses confirm that the central core meaning of "Ḍalāl" is the denial of monotheism and the rejection of prophethood, and other instances of misguidance are, in a way, traceable back to these two principles. Consequently, it can be emphasized that the primary and ultimate instance of misguidance is deviation from monotheism and prophethood. This study further reveals the necessity of employing interpretive rules and multi-level exegesis for an accurate and profound understanding of such key concepts in the Noble Qur'an.